Computational Structural Biologist
ProteinQure
- Toronto, ON
- Permanent
- Full-time
- Develop novel drug candidates using our computational protein design platform with academic and industry partners
- Execution of protein design workflows (structure and property prediction)
- Data analysis and visualization for reports/presentations, delivery to partners
- Orchestrate platform validation for retrospective and prospective applications (may involve close interaction with experimental biologists at ProteinQure/CRO)
- Summarize and disseminate research on drug discovery targets, therapeutic modalities, and computational methodologies, to guide internal drug discovery and software development.
- Work side-by-side with chemists, biologists, computer scientists, and software developers to develop new methods for protein design
- Assist in the collection/curation of biological datasets (sequence, structure, function data) for machine learning initiatives
- Identification of platform limitations and development of research strategies to resolve these issues.
- PhD (or 2+ years experience) in Biochemistry, Bioinformatics, Biophysics or similar field
- Comfort explaining technical concepts to a diverse audience
- Peer-reviewed publications on protein engineering, design, structure and function OR Case studies from time in industry
- Experience with molecular modelling software (Rosetta, BioLuminate, MOE)
- Confidence with molecular visualization software (PyMol, Chimera, VMD)
- Scripting experience (Python) and knowledge of biology data formats (PDB)
- Experience with biophysical experiments (NMR, EPR, FRET, X-ray crystallography, etc.) or measuring protein-protein interactions (SPR, ITC, phage display)