Postdoctoral Fellow – Single-Cell Functional Genomics

University of British Columbia

  • Vancouver, BC
  • $50,000-60,000 per year
  • Permanent
  • Full-time
  • 16 days ago
AcademicJob Category Faculty Non BargainingJob Title Postdoctoral Fellow – Single-Cell Functional GenomicsDepartment Lack Laboratory | Department of Urologic Sciences | Faculty of Medicine (Nathan Lack)Posting End Date September 16, 2025Note: Applications will be accepted until 11:59 PM on the Posting End Date.Job End Date September 30, 2026The salary range for this Postdoctoral Fellowship is $50,000 to $60,000 per annum. Salary will be commensurate with qualifications and experience.The Lack Laboratory at the Vancouver Prostate Centre is recruiting a highly motivated Postdoctoral Research Fellow to lead the development of novel single-cell functional genomic approaches to identify therapeutic vulnerabilities in prostate cancer. This project integrates cutting-edge single-cell technologies and functional genomics to dissect mechanisms of treatment resistance and lineage plasticity in advanced prostate cancer.The successful candidate will join a dynamic, multidisciplinary team with strong ties to clinical programs and international collaborations.The Vancouver Prostate CentreThe VPC has a large number of multi-disciplinary research programs in basic, clinic, and translational cancer research. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research. It is affiliated with the University of British Columbia and the Vancouver Coastal Health Authority. Further details on VPC and its research programs are available at .Responsibilities
  • Design and implement an innovative ultra high-throughput functional genomic approach to profile enhancer dependencies.
  • Develop and optimize experimental workflows integrating scRNA-seq, scATAC-seq, and other single-cell omics.
  • Interpret high-dimensional data in collaboration with laboratories computational biologists.
  • Lead independent research projects and contribute to collaborative efforts within the lab.
  • Present findings in manuscripts, conferences, and funding applications.
  • Mentor junior researchers and contribute to a collegial lab environment.
Qualifications and Requirements
  • PhD in Molecular Biology, Genomics, Cancer Biology, or a related field.
  • Strong background in functional genomics, CRISPR-based screening, or single-cell technologies.
  • Hands-on experience with next-generation sequencing library prep and tissue culture models.
  • Demonstrated ability to conduct independent research and publish in peer-reviewed journals.
  • Excellent written and oral communication skills.
  • Experience with prostate cancer models or hormone-dependent cancers.
  • Familiarity with single-cell data analysis pipelines (e.g., Seurat, Scanpy, ArchR).
  • Prior exposure to high-throughput screening or pooled genetic perturbation methods.
What we offer
  • A supportive and collaborative research environment within one of Canada’s leading cancer research institutes.
  • Access to state-of-the-art single-cell, sequencing, and bioinformatics infrastructure.
  • Extensive opportunities for career development, networking, and training.
  • Competitive salary and benefits, commensurate with experience and UBC standards.
Application ProceduresTo apply, please send the following documents to Nathan Lack ( ):
  • A cover letter describing your research interests and fit for the position
  • A current CV with a list of publications
  • Contact information for 2–3 academic references

University of British Columbia