Senior Scientist, Bioinformatics, Oncology R&D
AstraZeneca
- Mississauga, ON
- Permanent
- Full-time
- Analyze late-stage clinical trials in immunotherapies to provide biological insights into patient response, using clinical data and rich patient genomic data, and guide clinical development strategies for future trials
- Apply the latest computational/systems biology approaches to the wealth of AZ Oncology clinical trial and real-world data; proactively devise and implement innovative bioinformatic solutions with a focus on immuno-oncology
- Use your knowledge of cancer biology, drug development and data science to deliver actionable impacts for cross-portfolio tumor strategy
- Collaborate closely with our Translational Medicine Leads to drive effective data generation from clinical trials and help address technology/analytics gaps
- Contribute bioinformatics expertise to the application and development of cutting-edge technologies in key strategic growth areas
- Publish work in high impact journals with industry and academic partners to increase visibility of AZ data science
- Relevant PhD (or equivalent graduate degree plus proven applied experience), combining technical expertise in computational biology, bioinformatics, data science or applied biostatistics
- A solid understanding of the molecular and/or immunological mechanisms driving cancer
- Skilled in effective communication of complex data, analysis and results to non-computational scientists and partner lines
- The ability to successfully work in a matrix setting and manage multiple simultaneous priorities on tight deadlines
- Familiarity with bioinformatics algorithms and toolkits; Programming proficiency in a Linux environment of high performance computing
- Experience and knowledge with data from clinical trials is strongly desired; expertise in ctDNA/liquid biopsy, single-cell technologies or spatial omics would also be a plus